Flash freezing is the process of rapidly lowering the temperature of a liquid so that larger ice crystals do not have the chance to form. These larger crystals can potentially damage proteins and other critical components of the liquid. Flash freezing is a common process for freezing bulk drug substance (BDS) and can lead to failure of typical BDS containers.

Evidence from this study indicates that Savillex 1 L Purillex PFA bottles are suitable for dry heat sterilization at 250°C for 120 minutes and then flash freezing down to liquid nitrogen temperatures (-196°C) with no bottle collapse and no loss of bottle integrity. Several of the tested bottles passed integrity testing after exposure to a second flash freezing cycle. This is a testament to the structural durability of fluoropolymer materials when exposed to temperature extremes. It is also illustrative of the strength and reliability of the Purillex bottle seal technology.

Evidence from this test protocol indicates that Savillex 1 L Purillex PFA bottles are suitable for dry heat sterilization at 250°C for 120 minutes and then flash freezing down to liquid nitrogen temperatures (-196°C) with no bottle collapse and no loss of bottle integrity. Several of the tested bottles passed integrity testing after exposure to a second flash freezing cycle. This is a testament to the structural durability of fluoropolymer materials when exposed to temperature extremes. It is also illustrative of the strength and reliability of the Purillex bottle seal technology.

Flash Freezing in Fluoropolymer Bottles

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The SCP SCIENCE DigiPREP family of digestion systems are specifically designed and manufactured with graphite block technology to offer superior performance in harsh laboratory environments. All have a non-metallic construction with a corrosion resistant case and a protective coated graphite block. This eliminates sample contamination from the instrument, resists aggressive corrosive attack, ensuring longevity of the system.

There are DigiPREP systems to suit every size laboratory and all operate with either a simple to use key pad controller or the multi-method colour touch screen controller. Together with innovative accessories, such as the DigiPROBE sample temperature controller, DigiTUBE disposable tubes and watchglasses, DigiFILTER filtration system, DigiPREP digestion systems meet all the sample digestion and evaporation needs of analytical chemists and spectroscopists.

Please CLICK HERE for more information.

We are delighted to once again be supporting the Breast Cancer Awareness Campaign by making a donation for every pack of limited edition PINK Caps or Vials we supply, whilst stocks last.

Limited editionTHINK PINK! products available include Low Volume Polypropylene Vials, 9mm Screw Caps, Snap Caps and Stackable Vial Rack:

    V1850    500μl Pink Polypropylene Robotic Vial, 9mm Thread
    V1851    500µl Pink Polypropylene 11mm CR/Snap Ring

    V1800    9mm Cap, Pink, PTFE/Red Rubber
    V1801    9mm Cap, Pink, PTFE/Silicone
    V1802    9mm Cap, Pink, PTFE/Silicone/PTFE
    V1803    9mm Cap, Pink, PTFE/Silicone with Slit

    V1855    11mm Snap Top Cap, Pink,with Starburst
    V1856    11mm Snap Top Cap, Pink,10mil PTFE Lined
    V1857    11mm Snap Top Cap, Pink,PTFE/Butyl Rubber Lined
    V1858    11mm Snap Top Cap, Pink,PTFE/Silicone Lined
    V1859    11mm Snap Top Cap, Pink,PTFE/Silicone/PTFE Lined
    V1860    11mm Snap Top Cap, Pink,PTFE/Silicone with Slit Lined
    V2129    50 Position Pink Stackable Rack for 12mm Vials

Our large range of pharmaceutical reference standards include active ingredients, their metabolites and impurities together with stable isotope analogues. These reference standards are synthesised, rigorously tested and certified, ready for use.  New compounds are regularly added to the range as synthesis projects progress to meet demand from pharmaceutical, government, clinical and other regulatory and diagnostic laboratories.  If you can't find the compound you require please contact us.

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Qmx Laboratories will be hosting two free one-day seminars for scientists with an interest in spectroscopic analysis, focusing on clean chemistry. 

Presented in conjunction with our colleagues at Savillex, the seminars will introduce new and innovative techniques and products designed to enhance ICP-OES / ICP-MS analysis, eliminate contamination and improve productivity.  A buffet lunch will be provided for all delegates, free of charge.

Registration is free but places are extremely limited and allocated on a strictly first come first served basis, so be sure to register at one of the following venues as soon as possible:

Tuesday 10th September - Durham University 
Thursday 12th September - University of Oxford

CLICK here to reserve your place.